INSILICO DESIGNING OF POTENT DRUG TARGETED TO SJOGREN’S SYNDROME ANTIGEN LA (SSB) OF SYSTEMATIC LUPUS ERYTHEMATOSUS

Ashish Kumar Mishra, ManasRanjan Barik

Abstract: An autoimmune disease has always been an eye candy for researchers. There have been plenty of researches done all over the world on the various autoimmune diseases. Systemic Lupus Erythematosus (SLE) is one such kind disease which lacks a complete cure. Various databases concluded on targeting the sjogren syndrome antigen B (SSB) gene. The role of SSB gene in SLE is very significant. The gene not only send wrong signal to the Apoptotic cells, but also produces auto antigens which causes the autoimmune disorder, causing the disease. The steps of this research will be including the sequence analysis followed by Phylogenetic analysis on the protein sequence. The structural analysis and drug molecule selection is also obtained. The selected drug molecules are tested for LIPINSKI rule of 5 and ADMET test. Those drugs which qualify the test are minimized along with the protein. Docking tools like HEX, Discovery Studio, and GOLD are used to analyse the compound that binds best and targets the problematic La protein. After analysis, sterol proves to be the best compound.

Keywords: Autoimmune, Systematic Lupus Erythematosus, Sjogren Syndrome Antigen B (SSB) gene

DOI: https://doi.org/10.15623/ijret.2016.0511027