ANTIOXIDANT STUDY OF USNIC ACID AND ITS DERIVATIVE USNIC ACID DIACETATE

R. Ananthi, A. Tinabaye, G. Selvaraj

Abstract: Currently interest towards the study of antioxidant efficiency of the lichen metabolites was given prior attention in the field of research. As the free radical accumulation in human cells causes several chronic diseases which can be eliminated with the help of antioxidants. In our present study we have isolated the lichen secondary metabolite Usnic acid from Usnea luridorufa and also prepared the acetyl derivative of Usnic acid. The in vitro antioxidant activity of Usnic acid and Usnic acid diacetate under DPPH free radical scavenging, FRAP, Superoxide dismutase activity, Metal chelating activity, Phosphomolybdenum activity, Hydroxyl scavenging activity, Lipid peroxidation inhibiting activity were studied. The antioxidant potential of the Usnic acid and its derivative Usnic acid diacetate were compared. The IC50 value are also determined. Both the test compounds possesses significant antioxidant activity under the studies.

Keywords: Antioxidant efficiency, Usnic acid, diacetate, Tannic acid

DOI: https://doi.org/10.15623/ijret.2015.0402047