SYNTHESIS, CHARACTERISATION AND ANTIBACTERIAL ACTIVITY OF COPOLYMER (N-VINYLPYRROLIDONE – MALEIC ANHYDRIDE) WITH N- DIETHYLETHANOLAMINE

Hemalatha P, M K Veeraiah, Prasannakumar S, Anasuya K V

Abstract: A copolymer of N-vinylpyrrolidone (NVP) with maleic anhydride (MA) is synthesized by radical copolymerization with 2,2-Azobisisobutyronitrile(AIBN) as initiator at 650C in dioxane solution, under nitrogen atmosphere. The copolymer obtained is characterized by FTIR and NMR. The copolymer is made to interact with N,N-Diethylaminoethanol (DEAE) in different ratios. The susceptibility of some Gram - negative bacteria like Klebsiella aerogenes NCIM-2098, Escherichia coli NCIM-5051, Pseudomonasaeruginosa NCIM2242, Pseudomonas desmolyticum NCIM-2028 and a Gram positive bacteria Staphylococcus aureus NCIM-5022, to the copolymer and its compound with N,N-Diethylaminoethanol of different compositions in microbiological medium is studied by Agar well diffusion method. The resulting polymeric antibacterial material is useful in a number of medicines and food industry

Keywords: N-vinylpyrrolidone, Maleic anhydride, Copolymerization, N, N-diethylaminoethanol, FTIR, NMR, Antibacterial activity.

DOI: https://doi.org/10.15623/ijret.2014.0303011