UNRAVELLING THE MOLECULAR LINKAGE OF CO-MORBID DISEASES: DIABETES MELLITUS, HYPERTENSION AND CORONARY ARTERY DISEASE

Varun Moganti, Abhinandita Dash

Abstract: The incidence of Diabetes Mellitus (DM), Hypertension (HTN) and Coronary artery disease (CAD) in the country has increased alarmingly. Since decades DM and HTN have been proved to be independent risk factors for CAD. Gene and its regulatory action through a protein are vital for the normal metabolism. Any abnormality in regulation would lead to a disease. Our study used the principles of network biology to understand the comorbidity of diseases at the molecular level. We have collected disease genes of DM, HTN and CAD from various public databases and extracted genes common to all the three diseases. We constructed a biological network by considering the protein interaction data obtained from Human Protein Reference Database (HPRD).The network was validated using power law distribution and the genes were ranked using Centiscape. Finally we identified the crucial genes with literature validation which could play a major role in causing disease co-morbidity

Keywords: Biological Network, Coronary Artery Disease, Diabetes Mellitus, Hypertension and Systems Biology

DOI: https://doi.org/10.15623/ijret.2013.0212018